The Smoky Mountains are home to 66 species of mammals, over 240 species of birds, 43 species of amphibians, 60 species of fish, and 40 species of reptiles. Some of the best places to spot wildlife in the  Great Smokies is along the loop road at Cades Cove and Roaring Fork and also Cataloochee Valley on the North Carolina side of the Smokies.